Medically the review by Alan Carter, Pharm.D. — written by Jill Seladi-Schulman, Ph.D. On December 19, 2018

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Acetaminophen (Tylenol) and also ibuprofen (Advil) space both over-the-counter (OTC) drugs that have the right to be provided to relieve pain.

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These medications are two different species of pain relievers. Acetaminophen, sometimes noted as APAP, is its own type, while ibuprofen is a nonsteroid anti-inflammatory drug (NSAID).

Generally, it’s safe to take acetaminophen and ibuprofen together, yet you’ll desire to salary close attention to how much you take it of every medication.

The vital to safely acquisition acetaminophen and ibuprofen is knowing just how much you’re acquisition at a time and also how often.

Acetaminophen dosage

The maximum for sure dosage of acetaminophen for anyone end the age of 12 is 4,000 milligrams (mg) every day. Yet even this quantity can damage some people’s livers, therefore aim because that no much more than 3,000 mg per day.

For children under the period of 12, it’s finest to inspect with their healthcare provider to recognize the safest dose for your body weight.

Keep in mind that numerous OTC medicines contain acetaminophen in a range of doses, typically 325 mg, 500 mg, or 650 mg.

Some instances of brand-name OTC medications that may contain paracetamol include:


Remember: when looking at labels, girlfriend might also see acetaminophen detailed as APAP.

Ibuprofen dosage

Avoid taking more that 1,200 mg of ibufrofen in a single day. OTC ib frames is often discovered in 200 mg pills. This translates to six pills a day. Still, girlfriend should constantly verify how much is in each pill.

Again, for children, it’s best to asking their medical care provider around the safest sheep for their weight.

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If you have prescription-strength ibuprofen, talk to your prescriber before mixing it with any kind of other medications, consisting of acetaminophen.


The recommended boundaries for adults and children over 12 are:

3,000 mg per day that acetaminophen1,200 mg per day of ibuprofen

For children under the age of 12, call their medical care provider or refer to the product label for dosage guidelines.

You can take ibuprofen and also acetaminophen at the very same time. Simply make certain to no take an ext than the recommended dose.

Some civilization experience some stomach or abdominal pain as soon as taking the two drugs together. In this case, it’s far better to alternate when you take it each medication.

For example, you might take ibufrofen first, followed by acetaminophen four hours later, and also then repeat this procedure as needed.

You could likewise alternate days. Because that example, if you take it ibuprofen top top Monday, take paracetamol on Tuesday and also so on.